População Residente - SergipePopulação Resident segundo MunicípioMunicípio: AracajuPeríodo: 2005
Município
População Resident
Fonte: IBGE - Censos Demográficos e Contagem Populacional; para os anos intercensitários, estimativas preliminares dos totais populacionais, estratificadas por idade e sexo pelo MS/SE/Datasus.Ver nota técnica.Consulte o site da Secretaria Estadual de Saúde para mais informações.
TOTAL
498.618
280030 Aracaju
498.618
Copia como .CSV
Copia para TabWin
quarta-feira, 16 de abril de 2008
Datasus
Mortalidade - Sergipe
Óbitos p/Residênc segundo MunicípioMunicípio: AracajuPeríodo: 2005
Município
Óbitos p/Residênc
Fonte: MS/SVS/DASIS - Sistema de Informações sobre Mortalidade - SIMConsulte o site da Secretaria Estadual de Saúde para mais informações.
TOTAL
2.774
280030 Aracaju
2.774
Óbitos p/Residênc segundo MunicípioMunicípio: AracajuPeríodo: 2005
Município
Óbitos p/Residênc
Fonte: MS/SVS/DASIS - Sistema de Informações sobre Mortalidade - SIMConsulte o site da Secretaria Estadual de Saúde para mais informações.
TOTAL
2.774
280030 Aracaju
2.774
quarta-feira, 9 de abril de 2008
PESQUISA DA ANVISA
Brasília, 4 de abril de 2008 - 17h40 Propaganda de analgésicos e tratamento da dengue
Em virtude da ocorrência de casos de dengue no Rio de Janeiro, a Agência Nacional de Vigilância Sanitária (Anvisa) solicitou formalmente à Associação Brasileira da Indústria de Medicamentos Isentos de Prescrição (Abimip) que oriente os fabricantes de analgésicos para a necessidade de suspensão temporária da propaganda desses medicamentos. Essa medida tem a intenção de impedir que a população faça uso abusivo das substâncias analgésicas.
O uso desses medicamentos pode retardar os sintomas da dengue, dificultando o diagnóstico e atrasando o tratamento da doença.
Informações: Ascom/Assessoria de Imprensa da Anvisa
PESQUISA PUBMED
Mathematical Modeling and Analysis Group (T-7), Theoretical Division (MS B284), Los Alamos National Laboratory, Los Alamos, NM, USA.
SUMMARYThe weekly number of dengue cases in Peru, South America, stratified by province for the period 1994-2006 were analysed in conjunction with associated demographic, geographic and climatological data. Estimates of the reproduction number, moderately correlated with population size (Spearman rho=0.28, P=0.03), had a median of 1.76 (IQR 0.83-4.46). The distributions of dengue attack rates and epidemic durations follow power-law (Pareto) distributions (coefficient of determination >85%, P<0.004). Spatial heterogeneity of attack rates was highest in coastal areas followed by mountain and jungle areas. Our findings suggest a hierarchy of transmission events during the large 2000-2001 epidemic from large to small population areas when serotypes DEN-3 and DEN-4 were first identified (Spearman rho=-0.43, P=0.03). The need for spatial and temporal dengue epidemic data with a high degree of resolution not only increases our understanding of the dynamics of dengue but will also generate new hypotheses and provide a platform for testing innovative control policies.
PMID: 18394264 [PubMed - as supplied by publisher]
SUMMARYThe weekly number of dengue cases in Peru, South America, stratified by province for the period 1994-2006 were analysed in conjunction with associated demographic, geographic and climatological data. Estimates of the reproduction number, moderately correlated with population size (Spearman rho=0.28, P=0.03), had a median of 1.76 (IQR 0.83-4.46). The distributions of dengue attack rates and epidemic durations follow power-law (Pareto) distributions (coefficient of determination >85%, P<0.004). Spatial heterogeneity of attack rates was highest in coastal areas followed by mountain and jungle areas. Our findings suggest a hierarchy of transmission events during the large 2000-2001 epidemic from large to small population areas when serotypes DEN-3 and DEN-4 were first identified (Spearman rho=-0.43, P=0.03). The need for spatial and temporal dengue epidemic data with a high degree of resolution not only increases our understanding of the dynamics of dengue but will also generate new hypotheses and provide a platform for testing innovative control policies.
PMID: 18394264 [PubMed - as supplied by publisher]
quarta-feira, 2 de abril de 2008
quarta-feira, 26 de março de 2008
High genetic stability of dengue virus propagated in MRC-5 cells as compared to the virus propagated in vero cells.
Liu CC, Lee SC, Butler M, Wu SC.
Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan.
This work investigated the replication kinetics of the four dengue virus serotypes (DEN-1 to DEN-4), including dengue virus type 4 (DEN-4) recovered from an infectious cDNA clone, in Vero cells and in MRC-5 cells grown on Cytodex 1 microcarriers. DEN-1 strain Hawaii, DEN-2 strain NGC, DEN-3 strain H-87, and DEN-4 strain H-241 , and DEN-4 strain 814669 derived from cloned DNA, were used to infect Vero cells and MRC-5 cells grown in serum-free or serum-containing microcarrier cultures. Serum-free and serum-containing cultures were found to yield comparable titers of these viruses. The cloned DNA-derived DEN-4 started genetically more homogeneous was used to investigate the genetic stability of the virus propagated in Vero cells and MRC-5 cells. Sequence analysis revealed that the DEN-4 propagated in MRC-5 cells maintained a high genetic stability, compared to the virus propagated in Vero cells. Amino acid substitutions of Gly(104)Cys and Phe(108)Ile were detected at 70%, 60%, respectively, in the envelope (E) protein of DEN-4 propagated in Vero cells, whereas a single mutation of Glu(345)Lys was detected at 50% in E of the virus propagated in MRC-5 cells. Sequencing of multiple clones of three separate DNA fragments spanning 40% of the genome also indicated that DEN-4 propagated in Vero cells contained a higher number of mutations than the virus growing in MRC-5 cells. Although Vero cells yielded a peak virus titer approximately 1 to 17 folds higher than MRC-5 cells, cloned DEN-4 from MRC-5 cells maintained a greater stability than the virus from Vero cells. Serum-free microcarrier cultures of MRC-5 cells offer a potentially valuable system for the large-scale production of live-attenuated DEN vaccines.
PMID: 18350148 [PubMed - in process]
PMCID: PMC2265545
Institute of Biotechnology, Department of Life Science, National Tsing Hua University, Hsinchu, Taiwan.
This work investigated the replication kinetics of the four dengue virus serotypes (DEN-1 to DEN-4), including dengue virus type 4 (DEN-4) recovered from an infectious cDNA clone, in Vero cells and in MRC-5 cells grown on Cytodex 1 microcarriers. DEN-1 strain Hawaii, DEN-2 strain NGC, DEN-3 strain H-87, and DEN-4 strain H-241 , and DEN-4 strain 814669 derived from cloned DNA, were used to infect Vero cells and MRC-5 cells grown in serum-free or serum-containing microcarrier cultures. Serum-free and serum-containing cultures were found to yield comparable titers of these viruses. The cloned DNA-derived DEN-4 started genetically more homogeneous was used to investigate the genetic stability of the virus propagated in Vero cells and MRC-5 cells. Sequence analysis revealed that the DEN-4 propagated in MRC-5 cells maintained a high genetic stability, compared to the virus propagated in Vero cells. Amino acid substitutions of Gly(104)Cys and Phe(108)Ile were detected at 70%, 60%, respectively, in the envelope (E) protein of DEN-4 propagated in Vero cells, whereas a single mutation of Glu(345)Lys was detected at 50% in E of the virus propagated in MRC-5 cells. Sequencing of multiple clones of three separate DNA fragments spanning 40% of the genome also indicated that DEN-4 propagated in Vero cells contained a higher number of mutations than the virus growing in MRC-5 cells. Although Vero cells yielded a peak virus titer approximately 1 to 17 folds higher than MRC-5 cells, cloned DEN-4 from MRC-5 cells maintained a greater stability than the virus from Vero cells. Serum-free microcarrier cultures of MRC-5 cells offer a potentially valuable system for the large-scale production of live-attenuated DEN vaccines.
PMID: 18350148 [PubMed - in process]
PMCID: PMC2265545
quarta-feira, 12 de março de 2008
PESQUISA LILACS
Base de dados : LILACS
Pesquisa : "DENGUE hemorragica" [Descritor de assunto]
Referências encontradas : 140 [refinar]
Mostrando: 1 .. 10 no formato [Detalhado]
Pesquisa : "DENGUE hemorragica" [Descritor de assunto]
Referências encontradas : 140 [refinar]
Mostrando: 1 .. 10 no formato [Detalhado]
Assinar:
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